Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cells.

@article{Chen2008CalmodulinBT,
  title={Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cells.},
  author={Yabing Chen and Pritish S Pawar and George Pan and Liping Ma and Hui Liu and J. M. Mcdonald},
  journal={Journal of cellular biochemistry},
  year={2008},
  volume={103 3},
  pages={788-99}
}
We have previously demonstrated that the antagonists of calmodulin (CaM) induce apoptosis of cholangiocarcinoma cells partially through Fas-mediated apoptosis pathways. Recently, CaM has been shown to bind to Fas, which is regulated during Fas or CaM antagonist-mediated apoptosis in Jurkat cells and osteoclasts. Accordingly, the present studies were designed to determine whether Fas interacts with CaM in cholangiocarcinoma cells and to elucidate its role in regulating Fas-mediated apoptosis… CONTINUE READING

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