Calmodulin antagonists inhibit endothelium-dependent hyperpolarization in the canine coronary artery.

@article{Nagao1992CalmodulinAI,
  title={Calmodulin antagonists inhibit endothelium-dependent hyperpolarization in the canine coronary artery.},
  author={Taku Nagao and S C Illiano and Paul Michel Vanhoutte},
  journal={British journal of pharmacology},
  year={1992},
  volume={107 2},
  pages={382-6}
}
1. The effects of the calmodulin antagonists, calmidazolium and fendiline were investigated on endothelium-dependent hyperpolarization in the canine coronary artery. The membrane potential of vascular smooth muscle cells was measured with the microelectrode technique. 2. Smooth muscle cells of the canine coronary artery had a resting membrane potential of -50 mV. Bradykinin and the Ca(2+)-ionophore, A23187, induced concentration- and endothelium-dependent hyperpolarization. The… CONTINUE READING
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