Calmodulin and the regulation of smooth muscle contraction

@article{Walsh2004CalmodulinAT,
  title={Calmodulin and the regulation of smooth muscle contraction},
  author={Michael P Walsh},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={135},
  pages={21-41}
}
  • M. Walsh
  • Published 2004
  • Chemistry, Medicine
  • Molecular and Cellular Biochemistry
Calmodulin, the ubiquitous and multifunctional Ca2+-binding protein, mediates many of the regulatory effects of Ca2+, including the contractile state of smooth muscle. The principal function of calmodulin in smooth muscle is to activate crossbridge cycling and the development of force in response to a [Ca2+]i transientvia the activation of myosin light-chain kinase and phosphorylation of myosin. A distinct calmodulin-dependent kinase, Ca2+/calmodulin-dependent protein kinase II, has been… Expand
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