Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS.

@article{Fritz2000CalmodulinAS,
  title={Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS.},
  author={Janice L Fritz and M F Vanberkum},
  journal={Development},
  year={2000},
  volume={127 9},
  pages={
          1991-2000
        }
}
The establishment of axon trajectories is ultimately determined by the integration of intracellular signaling pathways. Here, a genetic approach in Drosophila has demonstrated that both Calmodulin and Son of sevenless signaling pathways are used to regulate which axons cross the midline. A loss in either signaling pathway leads to abnormal projection of axons across the midline and these increase with roundabout or slit mutations. When both Calmodulin and Son of sevenless are disrupted, the… CONTINUE READING
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