Calmodulin and protein kinase C regulate gap junctional coupling in lens epithelial cells.

  title={Calmodulin and protein kinase C regulate gap junctional coupling in lens epithelial cells.},
  author={Monica M Lurtz and Charles Francis Louis},
  journal={American journal of physiology. Cell physiology},
  volume={285 6},
The mechanisms regulating the permeability of lens epithelial cell gap junctions in response to calcium ionophore or ATP agonist-mediated increases in cytosolic Ca2+ (Cai2+) have been investigated using inhibitors of calmodulin (CaM) and PKC. Cell-to-cell transfer of the fluorescent dye AlexaFluor594 decreased after the rapid and sustained increase in Cai2+ (to micromolar concentrations) observed after the addition of ionophore plus Ca2+ but was prevented by pretreatment with inhibitors of CaM… CONTINUE READING


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