Calmodulin activation is required for the enhancement of hippocampal neurogenesis following environmental enrichment

  title={Calmodulin activation is required for the enhancement of hippocampal neurogenesis following environmental enrichment},
  author={Le Zhong and Chong-huai Yan and Cheng-qiu Lu and Jian Xu and Hua Huang and Xiao-ming Shen},
  journal={Neurological Research},
  pages={707 - 713}
Abstract Objective: An enriched environmental exposure has been shown to promote hippocampal neurogenesis, which is an important mechanism underlying enrichment-induced memory improvement. The cAMP response element-binding protein is an important stimulus-inducible factor in the brain and is crucial for neurogenesis and memory ability. Calmodulin activation is important for activity-induced cAMP response element-binding protein phosphorylation. The aim of this study was to explore the effects… 
Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment.
EE improved cognitive function, and increased the proliferation, differentiation and survival of newly‑formed neurons in the DG of adult rats; however, EE did not activate neurogenesis in the SVZ, which provides a theoretical basis to explain the beneficial effects of EE on healthy, adult rats.
Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory.
This review aims to ascertain the role of several important feeding peptides in cognitive functions, either through their local synthesis in the hippocampus or through their actions via specific receptors inThe hippocampus.
The Influence of Housing, Sex and Strain on Baseline and Drug-Induced Behavioural and Neurochemical Parameters in the Rat
A number of confounding factors are believed to affect both basal rodent behaviour and responsivity to psychotropic drugs. To date, few detailed comparative assessments of these confounds have been
The Beneficial Effect of Enriched Environment on Pathogenesis of Alzheimer’s Disease
The effects of EE on learning ability, memory ability and mental behavior in AD are explained, and a new direction for the treatment and rehabilitation of AD is provided.
Exercising New Neurons to Vanquish Alzheimer Disease
Current evidence supporting the putative therapeutic potential of EE and physical exercise to increase AHN and hippocampal plasticity both under physiological and pathological circumstances are summarized, with a special emphasis on neurodegenerative diseases and AD.
Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students
Investigation of changes in the levels of the KP neuroactive metabolites and cytokines in response to stress triggered by academic examinations found the concomitant increased levels of BDNF under the duress of acute examination stress appear to limit the levels pro-inflammatory markers, which may attenuate the action of cortisol and the neuroinflammatory branch ofThe KP.
Musical practice and BDNF plasma levels as a potential marker of synaptic plasticity: an instrument of rehabilitative processes
Assuming BDNF PLs to be a marker of synaptic plasticity, higher PLs could be associated with the activation of alternative neural pathways: a lower score in the “attention to detail” sub-scale could imply greater flexibility of higher cerebral functions among musicians.


[Preweaning exposure to enriched environment induces hippocampal neurogenesis: experiment with rats].
Preweaning exposure to enriched environment can induce neurogenesis, and the underlying mechanism may be that enriched environment induces the activation of calmodulin and CREB in hippocampus.
Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment
It is concluded that BDNF but not NT‐4 is required for the environmental induction of neurogenesis, and failure to up‐regulate BDNF accompanied the lack of a neurogenic response in enriched BDNF heterozygous mice.
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment
It is established that newborn cells in the dentate gyrus contribute to the expression of the promnesic effects of behavioural enrichment, and they provide further support for the idea that adult‐generated neurons participate in modulating memory function.
Enriched Environment Influences Adrenocortical Response to Immune Challenge and Glutamate Receptor Gene Expression in Rat Hippocampus
Vulnerable to some negative effects of repeated immune challenge may be modified by environmental conditions associated with changes in brain plasticity, as shown in the case of Wistar rats.
[Effects of preweaning enrichment on activity-regulated cytoskeletal protein expression and long-term memory in rats].
Preweaning enrichment can up-regulate the expression of immediate early gene, Arc, in the hippocampus of the rats, and promote their long-term memory.
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
The results suggest that the cAMP–CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis.
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentates gyrus.
Enriched Environment Attenuates Cell Genesis in Subventricular Zone After Focal Ischemia in Mice and Decreases Migration of Newborn Cells to the Striatum
An enriched environment after experimental stroke increased neurogenesis in the hippocampus, whereas there was a decreased cell genesis and migration of neuroblasts and newborn astrocytes in the striatum.
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
It is shown that brief bursts of activity cause a swift (∼1 min) translocation of calmodulin from the cytoplasm to the nucleus, and that this translocation is important for the rapid phosphorylation of CREB.