Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels

@article{Kaneko2006CalmodulinCT,
  title={Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels},
  author={Hiromasa Kaneko and Frank M{\"o}hrlen and Stephan Frings},
  journal={The Journal of General Physiology},
  year={2006},
  volume={127},
  pages={737 - 748}
}
In sensory neurons of the peripheral nervous system, receptor potentials can be amplified by depolarizing Cl currents. In mammalian olfactory sensory neurons (OSNs), this anion-based signal amplification results from the sequential activation of two distinct types of transduction channels: cAMP-gated Ca channels and Ca-activated Cl channels. The Cl current increases the initial receptor current about 10-fold and leads to the excitation of the neuron. Here we examine the activation mechanism of… CONTINUE READING
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