Calmodulin: its potential role in cell proliferation and heavy metal toxicity.

  title={Calmodulin: its potential role in cell proliferation and heavy metal toxicity.},
  author={W. Y. Cheung},
  journal={Federation proceedings},
  volume={43 15},
Increasing evidence indicates that calmodulin, the ubiquitous Ca2+-binding protein in eukaryotes, serves as a major intracellular Ca2+ receptor regulating the activity or rate of many key enzymes and cellular processes, including a potential role in cell proliferation. Certain heavy metals are highly toxic to the cell; preliminary findings from our laboratory suggest that these metals effectively substitute for Ca2+ in calmodulin. Activation of calmodulin by these metals could upset its normal… CONTINUE READING

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