Calmodulin: its potential role in cell proliferation and heavy metal toxicity.

@article{Cheung1984CalmodulinIP,
  title={Calmodulin: its potential role in cell proliferation and heavy metal toxicity.},
  author={W. Y. Cheung},
  journal={Federation proceedings},
  year={1984},
  volume={43 15},
  pages={2995-9}
}
Increasing evidence indicates that calmodulin, the ubiquitous Ca2+-binding protein in eukaryotes, serves as a major intracellular Ca2+ receptor regulating the activity or rate of many key enzymes and cellular processes, including a potential role in cell proliferation. Certain heavy metals are highly toxic to the cell; preliminary findings from our laboratory suggest that these metals effectively substitute for Ca2+ in calmodulin. Activation of calmodulin by these metals could upset its normal… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Cadmium reduces nitric oxide production by impairing phosphorylation of endothelial nitric oxide synthase.

Biochemistry and cell biology = Biochimie et biologie cellulaire • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…