Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility.

@article{Ikawa2001CalmeginIR,
  title={Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility.},
  author={Masahito Ikawa and Tomoko Nakanishi and Shu-ichi Yamada and Ikuo Wada and Katsuya Kominami and Hideaki Tanaka and Masami Nozaki and Yoshitake Nishimune and Masaru Okabe},
  journal={Developmental biology},
  year={2001},
  volume={240 1},
  pages={254-61}
}
Loss of the endoplasmic reticulum resident chaperone calmegin leads to the production of sterile sperm that do not bind to the egg zona pellucida (M. Ikawa et al., 1997, Nature 387, 607-611). In the present study, we demonstrate that calmegin -/- sperm were defective in migrating into the oviducts and in binding to the egg plasma membrane. Despite the impaired adhesive function, calmegin -/- sperm could fertilize eggs when zonae pellucidae were partially dissected, and eggs fertilized in this… CONTINUE READING