Calin from Hirudo medicinalis, an inhibitor of von Willebrand factor binding to collagen under static and flow conditions.

@article{Hrsfalvi1995CalinFH,
  title={Calin from Hirudo medicinalis, an inhibitor of von Willebrand factor binding to collagen under static and flow conditions.},
  author={Jol{\'a}n H{\'a}rsfalvi and J. M. Stassen and Marc F. Hoylaerts and Emmanuel van Houtte and Roy T. Sawyer and Jos Vermylen and Hans Deckmyn},
  journal={Blood},
  year={1995},
  volume={85 3},
  pages={
          705-11
        }
}
  • Jolán Hársfalvi, J. M. Stassen, +4 authors Hans Deckmyn
  • Published in Blood 1995
  • Biology, Medicine
  • Calin from the saliva of the medicinal leech, Hirudo medicinalis, is a potent inhibitor of collagen mediated platelet adhesion and activation. In addition to inhibition of the direct platelet-collagen interaction, we presently demonstrate that binding of von Willebrand to coated collagen can be prevented by Calin, both under static and flow conditions in agreement with the occurrence of binding of Calin to collagen, confirmed by Biospecific Interaction Analysis. To define whether Calin acted by… CONTINUE READING

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