Calicivirus 3C-Like Proteinase Inhibits Cellular Translation by Cleavage of Poly(A)-Binding Protein

@article{KuyumcuMartinez2004Calicivirus3P,
  title={Calicivirus 3C-Like Proteinase Inhibits Cellular Translation by Cleavage of Poly(A)-Binding Protein},
  author={Muge N. Kuyumcu-Martinez and G. Belliot and S. Sosnovtsev and Kyeong-Ok Chang and K. Green and R. Lloyd},
  journal={Journal of Virology},
  year={2004},
  volume={78},
  pages={8172 - 8182}
}
ABSTRACT Caliciviruses are single-stranded RNA viruses that cause a wide range of diseases in both humans and animals, but little is known about the regulation of cellular translation during infection. We used two distinct calicivirus strains, MD145-12 (genus Norovirus) and feline calicivirus (FCV) (genus Vesivirus), to investigate potential strategies used by the caliciviruses to inhibit cellular translation. Recombinant 3C-like proteinases (r3CLpro) from norovirus and FCV were found to cleave… Expand

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