Calibration of the Andersen cascade impactor for the characterization of nasal products.

@article{Garmise2008CalibrationOT,
  title={Calibration of the Andersen cascade impactor for the characterization of nasal products.},
  author={Robert J. Garmise and Anthony JR Hickey},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 8},
  pages={3462-6}
}
Current cascade impactor protocols do not completely rule out nasal preparations entering the lower respiratory tract. A modified cascade impactor (MCI) was developed to characterize the particle size fraction capable of deposition in the lower respiratory tract. This is an important measure of the potential for delivery to a site which is not the route of administration, and which could lead to potential toxicity. Monodisperse aerosols were utilized to calibrate the Stage -2 and Stage -0 of an… CONTINUE READING
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