Calibration of credibility of agnostic genome-wide associations.

@article{Ioannidis2008CalibrationOC,
  title={Calibration of credibility of agnostic genome-wide associations.},
  author={John P. A. Ioannidis},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2008},
  volume={147B 6},
  pages={964-72}
}
Genome-wide testing platforms are increasingly used to promote "agnostic" approaches to the discovery of gene variants associated with the risk of many common diseases and quantitative traits. The early track record of genome-wide association (GWA) studies suggests that some proposed associations are replicated quite consistently with large-scale subsequent evidence from multiple studies, others have a more inconsistent replication record, some have failed to be replicated by independent… CONTINUE READING

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