Calibrated BOLD : measuring task-related changes in CMRO 2 at baseline and elevated CBF

Introduction: By using a gas challenge to determine the maximum possible blood-oxygenation-level-dependent (BOLD) response for a given region, calibrated BOLD techniques can measure relative changes in oxidative metabolism (CMRO2) induced by a task [1-3]. This process requires delivery of CO2 or O2 to the subject whilst acquiring ASL data to determine… (More)