Calhex₂₃₁ Ameliorates Cardiac Hypertrophy by Inhibiting Cellular Autophagy in Vivo and in Vitro.

@article{Liu2015CalhexAC,
  title={Calhex₂₃₁ Ameliorates Cardiac Hypertrophy by Inhibiting Cellular Autophagy in Vivo and in Vitro.},
  author={Lei Liu and Chao Wang and Dianjun Sun and Shuangquan Jiang and Hong Li and Weihua Zhang and Yajun Zhao and Yuhui Xi and Sa Shi and Fanghao Lu and Ye Tian and Changqing Xu and Li-na Wang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2015},
  volume={36 4},
  pages={1597-612}
}
BACKGROUND/AIMS Intracellular calcium concentration ([Ca2+]i) homeostasis, an initial factor of cardiac hypertrophy, is regulated by the calcium-sensing receptor (CaSR) and is associated with the formation of autolysosomes. The aim of this study was to investigate the role of Calhex231, a CaSR inhibitor, on the hypertrophic response via autophagy modulation. METHODS Cardiac hypertrophy was induced by transverse aortic constriction (TAC) in 40 male Wistar rats, while 10 rats underwent a sham… CONTINUE READING
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