Calditol-linked membrane lipids are required for acid tolerance in Sulfolobus acidocaldarius

  title={Calditol-linked membrane lipids are required for acid tolerance in Sulfolobus acidocaldarius},
  author={Z. Zeng and Xiao-Lei Liu and Jeremy H. Wei and R. Summons and P. Welander},
  journal={Proceedings of the National Academy of Sciences},
  pages={12932 - 12937}
Significance It is thought that the distinct ether lipid membranes of archaea allow them to thrive in environmental extremes. However, it has been difficult to demonstrate this physiological role directly. Here, we identify a protein required for the biosynthesis of a unique archaeal lipid head group, calditol, whose production was considered to be restricted to a subset of archaeal thermoacidophiles. We show that deletion of this protein in Sulfolobus acidocaldarius prevents production of… Expand
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Physiological Characterization of Sulfolobus acidocaldarius in a Controlled Bioreactor Environment


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