Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.

@article{Yoshio2007CaldesmonSC,
  title={Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.},
  author={Toshiyuki Yoshio and Tomotake Morita and Yayoi Kimura and Masahiko Tsujii and Naoyuki Hayashi and Kenji Sobue},
  journal={FEBS letters},
  year={2007},
  volume={581 20},
  pages={3777-82}
}
The podosome and invadopodium are dynamic cell-adhesion structures that degrade the extracellular matrix (ECM) and promote cell invasion. We recently reported that the actin-binding protein caldesmon is a pivotal regulator of podosome formation. Here, we analyzed the caldesmon's involvement in podosome/invadopodium-mediated invasion by transformed and cancer cells. The ectopic expression of caldesmon reduced the number of podosomes/invadopodia and decreased the ECM degradation activity… CONTINUE READING