Caldesmon and the regulation of cytoskeletal functions.

  title={Caldesmon and the regulation of cytoskeletal functions.},
  author={C L Albert Wang},
  journal={Advances in experimental medicine and biology},
  • C L Albert Wang
  • Published 2008 in Advances in experimental medicine and biology
Caldesmon (CaD) is an extraordinary actin-binding protein, because in addition to actin, it also bindsmyosin, calmodulin and tropomyosin. As a component of the smoothmuscle and nonmuscle contractile apparatus CaD inhibits the actomyosin ATPase activity and its inhibitory action is modulated by both Ca2+ and phosphorylation. The multiplicity of binding partners and diverse biochemical properties suggest CaD is a potent and versatile regulatory protein both in contractility and cell motility… CONTINUE READING

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