Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function.

@article{Wasik2013CalcyclinBP,
  title={Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function.},
  author={Urszula Wasik and Gabriela Schneider and Anna Mietelska-Porowska and Marcin Mazurkiewicz and Hanna Fabczak and Serge Weis and Claudia Zabke and Charles R. Harrington and Anna Filipek and Grażyna Niewiadomska},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 5},
  pages={1380-8}
}
The calcyclin binding protein and Siah-1 interacting protein (CacyBP/SIP) protein was shown to play a role in the organization of microtubules. In this work we have examined the neuronal distribution and possible function of CacyBP/SIP in cytoskeletal pathophysiology. We have used brain tissue from Alzheimer's disease (AD) patients and from transgenic mice modeling 2 different pathologies characteristic for AD: amyloid and tau. In the brain from AD patients, CacyBP/SIP was found to be almost… CONTINUE READING

Similar Papers

Loading similar papers…