Calculation procedures and HPLC method for analysis of the lipophilicity of acyclovir esters

  title={Calculation procedures and HPLC method for analysis of the lipophilicity of acyclovir esters},
  author={M. Lesniewska and Z. Gdaniec and I. Muszalska},
  journal={Drug Development and Industrial Pharmacy},
  pages={663 - 669}
Abstract Acyclovir (ACV) belongs to a class of drugs with low bioavailability. Selected ACV esters including acetyl (Ac-), isobutyryl (iBut-), pivaloyl (Piv-), ethoxycarbonyl (Etc-) and nicotinoyl (Nic-) were synthesized, and their lipophilicity was determined by the high-performance liquid chromatography (HPLC) RP method. Statistical analyses of the comparative values of log P and clog P were carried out using computational methods. It was proved that the AC log P algorithm can be useful for… Expand
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