Calculation of the antibiotic level in the lung tissue and bronchial secretion with an oral controlled-release dosage form

@article{Sadna1998CalculationOT,
  title={Calculation of the antibiotic level in the lung tissue and bronchial secretion with an oral controlled-release dosage form},
  author={M. Sa{\"i}dna and E. M. Ouriemchi and Julien Vergnaud},
  journal={InflammoPharmacology},
  year={1998},
  volume={6},
  pages={321-337}
}
The drug level-time history in plasma and lung tissue was calculated with an antibiotic orally delivered in either an immediate-release or a controlled-release dosage form. The drug profiles were compared with experiment results given in the literature. In the same way, the drug level was evaluated in the bronchial secretion in contact with lung tissue. A numerical model, based on finite differences taking all the known facts into account was built and tested with the data found in the… CONTINUE READING