Calculation of binding isotherms for heterogeneous polymers.

  title={Calculation of binding isotherms for heterogeneous polymers.},
  author={D. M. Crothers},
  volume={6 4},
The matrix method of statistical mechanics is used to calculate equilibria for the binding of small molecules to polymers. When there is only one kind of binding site the problem is simple; some examples are given for illustrative purposes. If, however, the binding sites are not all equivalent and the bound molecules interact or interfere with each other, the problem is no longer trivial, being formally analogous with calculation of the helix-coil transition equilibrium in a heterogeneous… CONTINUE READING

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