Calculating pH and salt dependence of protein-protein binding.

  title={Calculating pH and salt dependence of protein-protein binding.},
  author={Jan H. Jensen},
  journal={Current pharmaceutical biotechnology},
  volume={9 2},
  • Jan H. Jensen
  • Published 2008 in Current pharmaceutical biotechnology
Ionic strength- (or salt-) effects on the protein-protein binding free energy has been included in many computational studies, while comparatively fewer computational studies have looked at the corresponding effect of pH. The pH dependence can be very complex if several groups change protonation state, while the ionic strength dependence usually scales as ln(I), and the main challenge is to predict the magnitude of the correlation. However, there is now very strong indication that pH effects… CONTINUE READING

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