Corpus ID: 4258005

Calculating normal tissue complication probabilities and probabilities of complication-free tumour control from stochastic models of population dynamics

@article{Hufton2018CalculatingNT,
  title={Calculating normal tissue complication probabilities and probabilities of complication-free tumour control from stochastic models of population dynamics},
  author={Peter G. Hufton and Elizabeth Buckingham-Jeffery and T. Galla},
  journal={arXiv: Populations and Evolution},
  year={2018}
}
  • Peter G. Hufton, Elizabeth Buckingham-Jeffery, T. Galla
  • Published 2018
  • Biology, Physics
  • arXiv: Populations and Evolution
  • We use a stochastic birth-death model for a population of cells to estimate the normal tissue complication probability (NTCP) under a particular radiotherapy protocol. We specifically allow for interaction between cells, via a nonlinear logistic growth model. To capture some of the effects of intrinsic noise in the population we develop several approximations of NTCP, using Kramers-Moyal expansion techniques. These approaches provide an approximation to the first and second moments of a general… CONTINUE READING

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