# Calculating normal tissue complication probabilities and probabilities of complication-free tumour control from stochastic models of population dynamics

@article{Hufton2018CalculatingNT, title={Calculating normal tissue complication probabilities and probabilities of complication-free tumour control from stochastic models of population dynamics}, author={Peter G. Hufton and Elizabeth Buckingham-Jeffery and T. Galla}, journal={arXiv: Populations and Evolution}, year={2018} }

We use a stochastic birth-death model for a population of cells to estimate the normal tissue complication probability (NTCP) under a particular radiotherapy protocol. We specifically allow for interaction between cells, via a nonlinear logistic growth model. To capture some of the effects of intrinsic noise in the population we develop several approximations of NTCP, using Kramers-Moyal expansion techniques. These approaches provide an approximation to the first and second moments of a general… CONTINUE READING

#### Paper Mentions

#### References

##### Publications referenced by this paper.

SHOWING 1-10 OF 18 REFERENCES