Calculating independent contrasts for the comparative study of substitution rates.

@article{Welch2008CalculatingIC,
  title={Calculating independent contrasts for the comparative study of substitution rates.},
  author={John J. Welch and David J Waxman},
  journal={Journal of theoretical biology},
  year={2008},
  volume={251 4},
  pages={667-78}
}
Phylogenetic comparative methods have been used to study patterns of correlated evolution between biological traits of all kinds, and are increasingly used to identify predictors of the rate of DNA substitution. Substitution rate differs from most traits studied in that it cannot be observed directly, but must be inferred from substitutions accrued over a long period of time. Studying a mathematical model of trait and rate evolution, we show that the special nature of substitution rates can… CONTINUE READING