Calculating Occupancy when One does not have Baseline: A Comparison of Different Options

  title={Calculating Occupancy when One does not have Baseline: A Comparison of Different Options},
  author={Euitae Kim and O. Howes and Kyung-Sang Yu and J. Jeong and J. Lee and I. Jang and Sang-Goo Shin and S. Kapur and J. Kwon},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  pages={1760 - 1767}
Dopamine D2 receptor occupancy of antipsychotic drugs is calculated relative to the subject's D2 receptor binding potential (BP) in the drug-free state (baseline BP). Because baseline BP is seldom known in patients with schizophrenia, population means from unrelated control samples are often used to estimate it. However, this is likely to introduce bias and error into the occupancy measure. There is thus a need for a method to reliably estimate baseline BP for patient populations in whom it may… Expand
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