Calculated and experimental absolute stereochemistry of the styrene and .beta.-methylstyrene epoxides formed by cytochrome P 450cam

@article{Fruetel1992CalculatedAE,
  title={Calculated and experimental absolute stereochemistry of the styrene and .beta.-methylstyrene epoxides formed by cytochrome P 450cam},
  author={J. Fruetel and J. Collins and D. L. Camper and G. Loew and P. R. Montellano},
  journal={Journal of the American Chemical Society},
  year={1992},
  volume={114},
  pages={6987-6993}
}
Cytochrome P450 cam oxidizes styrene to styrene oxide and a trace of phenylacetaldehyde; cis-β-methylstyrene to cis-β-methylstyrene oxide, cis-3-phenyl-2-propen-1-ol, and a trace of 1-phenyl-2-propanone; and trans-β-methylstyrene to trans-β-methylstyrene oxide, trans-3-phenyl-2-propen-1-ol, and a trace of 1-phenyl-2-propanone. Aromatic ring hydroxylation is also observed as a very minor process with each of the three substrates. Benzaldehyde is formed as a major product in all the reactions… Expand
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