Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures.

@article{Kunkler1998CalciumWP,
  title={Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures.},
  author={Phillip E. Kunkler and Richard P. Kraig},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 9},
  pages={3416-25}
}
Although intercellular Ca2+ waves resemble spreading depression (SD) and occur in hippocampal organ cultures (HOTCs), SD has not been reported in these cultures. Accordingly, electrophysiological and Ca2+ imaging techniques were used to examine potential interrelations between Ca2+ waves and electrophysiological changes of SD. Our results show, for the first time, that HOTCs can support SD. Furthermore, two distinct Ca2+ waves were found to precede SD. The first traveled >100 micron/sec along… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 77 references

The mechanism and applications of Leão’s spreading depression of electroencephalographic activity

J Bureś, O Bureŝova, J Krr̆ivánek
1974
View 16 Excerpts
Highly Influenced

Calcium waves in retinal glial cells.

View 7 Excerpts
Highly Influenced

Propagating calcium waves precede spreading depression

PE Kunkler, RP Kraig
Ann Neurol 42:A435 • 1997
View 6 Excerpts
Highly Influenced

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