Calcium uptake via endocytosis with rapid release from acidifying endosomes

  title={Calcium uptake via endocytosis with rapid release from acidifying endosomes},
  author={Julia V Gerasimenko and Alexei V Tepikin and Ole H Petersen and Oleg V Gerasimenko},
  journal={Current Biology},
A number of specific cellular Ca2+ uptake pathways have been described in many different cell types [1] [2] [3]. The possibility that substantial quantities of Ca2+ could be imported via endocytosis has essentially been ignored, although it has been recognized that endosomes can store Ca2+ [4] [5]. Exocrine cells can release significant amounts of Ca2+ via exocytosis [6], so we have investigated the fate of Ca2+ taken up via endocytosis into endosomes. Ca2+-sensitive and H+-sensitive… CONTINUE READING


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