Calcium uptake related to K+-depolarization and Na+/Ca2+ exchange in sheep brain synaptosomes.

Abstract

The uptake of Ca2+ by synaptosomes induced by K+-depolarization and by Na+/Ca2+ exchange was studied in synaptosomes in which the internal Na+ and K+ contents were varied by prolonged incubation at 30 degrees C or by inhibiting the Na+, K+-ATPase with 1 mM ouabain. Increased Na+ content of the synaptosomes is associated with an increase in Ca2+ uptake when… (More)

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