Calcium uptake and catecholamine secretion by cultured bovine adrenal medulla cells.

@article{Kilpatrick1982CalciumUA,
  title={Calcium uptake and catecholamine secretion by cultured bovine adrenal medulla cells.},
  author={Daniel L. Kilpatrick and R J Slepetis and James J. Corcoran and Norman Kirshner},
  journal={Journal of neurochemistry},
  year={1982},
  volume={38 2},
  pages={427-35}
}
The uptake of 45Ca2+ and secretion of catecholamines by primary cultures of adrenal medulla cells were studied. Nicotine, veratridine, potassium, and Ionomycin stimulate both the accumulation of 45Ca2+ and the secretion of catecholamines. Nicotinic antagonists block 45Ca2+ uptake induced by nicotine, tetrodotoxin blocks 45Ca2+ uptake induced by veratridine, and D600 or secretion induced by Ionomycin. The EC50 for nicotine is 3 microM for catecholamine secretion and 10 microM for 45Ca2+ uptake… CONTINUE READING

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