Calcium-triggered selective intermembrane exchange of phospholipids by the lung surfactant protein SP-A.

@article{Cajal1998CalciumtriggeredSI,
  title={Calcium-triggered selective intermembrane exchange of phospholipids by the lung surfactant protein SP-A.},
  author={Yolanda Cajal and Chandra Dodia and Aron B. Fisher and Mahendra Kumar Jain},
  journal={Biochemistry},
  year={1998},
  volume={37 35},
  pages={
          12178-88
        }
}
It is shown that human lung surfactant protein (SP-A) mediates selective exchange of phospholipid probes with unlabeled phospholipid in excess vesicles in the presence of calcium and NaCl. The exchange occurs without leakage of vesicle contents, or transbilayer movement (flip-flop) of the phospholipid probes, or fusion of vesicles. Individual steps preceding the exchange are dissected by a combination of protocols, and the results are operationally interpreted in terms of a model where a… CONTINUE READING
BETA