Calcium transients induce spatially coordinated increases in traction force during the movement of fish keratocytes.

@article{Doyle2004CalciumTI,
  title={Calcium transients induce spatially coordinated increases in traction force during the movement of fish keratocytes.},
  author={Andrew D. Doyle and William A Marganski and Juliet Lee},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 11},
  pages={2203-14}
}
The coordination of protrusion with retraction is essential for continuous cell movement. In fish keratocytes the activation of stretch-activated calcium channels, and the resulting increase in intracellular calcium, trigger release of the rear cell margin when forward movement is impeded. Although it is likely that retraction involves a calcium-dependent increase in cytoskeletal contractility, it is not known how the timing, magnitude and localization of contractile forces are organized during… CONTINUE READING
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