Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal.

@article{Piochon2016CalciumTS,
  title={Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal.},
  author={Claire Piochon and Heather K. Titley and Dana H Simmons and Giorgio Grasselli and Ype Elgersma and Christian R W Hansel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 46},
  pages={13221-13226}
}
At glutamatergic synapses, both long-term potentiation (LTP) and long-term depression (LTD) can be induced at the same synaptic activation frequency. Instructive signals determine whether LTP or LTD is induced, by modulating local calcium transients. Synapses maintain the ability to potentiate or depress over a wide frequency range, but it remains unknown… CONTINUE READING