Calcium sparks in smooth muscle.

  title={Calcium sparks in smooth muscle.},
  author={Jonathan H Jaggar and Valerie A Porter and W. Jonathan Lederer and Mark T. Nelson},
  journal={American journal of physiology. Cell physiology},
  volume={278 2},
Local intracellular Ca(2+) transients, termed Ca(2+) sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca(2+) release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca(2+) sparks are activated by Ca(2+) entry through dihydropyridine-sensitive voltage-dependent Ca(2+) channels, although the precise mechanisms of communication of Ca(2+) entry to Ca(2+) spark activation are not clear in smooth muscle. Ca(2+) sparks act as a positive-feedback element… CONTINUE READING
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