Calcium signalling silencing in atrial fibrillation.

  title={Calcium signalling silencing in atrial fibrillation.},
  author={Maura Greiser},
  journal={The Journal of physiology},
  volume={595 12},
Subcellular calcium signalling silencing is a novel and distinct cellular and molecular adaptive response to rapid cardiac activation. Calcium signalling silencing develops during short-term sustained rapid atrial activation as seen clinically during paroxysmal atrial fibrillation (AF). It is the first 'anti-arrhythmic' adaptive response in the setting of AF and appears to counteract the maladaptive changes that lead to intracellular Ca2+ signalling instability and Ca2+ -based arrhythmogenicity… CONTINUE READING
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