Calcium signalling in astrocytes and modulation of neural activity

  title={Calcium signalling in astrocytes and modulation of neural activity},
  author={Angelo Di Garbo and Michele Barbi and Santi Chillemi and Susanna Alloisio and Mario Nobile},
  journal={Bio Systems},
  volume={89 1-3},
Starting from the experimental data on ATP evoked calcium responses in astrocytes, a biophysical model describing these phenomena was built. The simulations showed, in agreement with the experimental findings, that the intracellular calcium fluxes mediated by the P2X and P2Y purinoreceptors are responsible for the biphasic ATP evoked calcium response in astrocytes. Then, the modulation effects on the neural dynamics arising from the release of glutamate from astrocyte are also investigated. By… CONTINUE READING

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ATP - induced , sustained signalling in cultured rat cortical astrocytes : evidence for a noncapacitive , P 2 X 7likemediated calcium entry

  • M. Nobile, I. Monaldi, S. Alloiso, C. Cugnoli, S Ferrosi
  • FEBS . Letters
  • 2003

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