Calcium signalling and pancreatic cell death: apoptosis or necrosis?


Secretagogues, such as cholecystokinin and acetylcholine, utilise a variety of second messengers (inositol trisphosphate, cADPR and nicotinic acid adenine dinucleotide phosphate) to induce specific oscillatory patterns of calcium (Ca2+) signals in pancreatic acinar cells. These are tightly controlled in a spatiotemporal manner, and are coupled to… (More)
DOI: 10.1038/sj.cdd.4402150


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