Calcium signaling inhibits interleukin-12 production and activates CD83(+) dendritic cells that induce Th2 cell development.

@article{Faries2001CalciumSI,
  title={Calcium signaling inhibits interleukin-12 production and activates CD83(+) dendritic cells that induce Th2 cell development.},
  author={Mark B Faries and Isabelle Bedrosian and S. Xu and Gary K. Koski and J G Roros and Mirielle A. Moise and H Q Nguyen and Friederike H. C. Engels and Peter A. Cohen and Brian J Czerniecki},
  journal={Blood},
  year={2001},
  volume={98 8},
  pages={
          2489-97
        }
}
Mature dendritic cells (DCs), in addition to providing costimulation, can define the Th1, in contrast to the Th2, nature of a T-cell response through the production of cytokines and chemokines. Because calcium signaling alone causes rapid DC maturation of both normal and transformed myeloid cells, it was evaluated whether calcium-mobilized DCs polarize T cells toward a Th1 or a Th2 phenotype. After human monocytes were cultured for 24 hours in serum-free medium and granulocyte-macrophage colony… 
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