Calcium signaling in cardiac myocytes.

  title={Calcium signaling in cardiac myocytes.},
  author={Claire J Fearnley and H Llewelyn Roderick and Martin D Bootman},
  journal={Cold Spring Harbor perspectives in biology},
  volume={3 11},
Calcium (Ca(2+)) is a critical regulator of cardiac myocyte function. Principally, Ca(2+) is the link between the electrical signals that pervade the heart and contraction of the myocytes to propel blood. In addition, Ca(2+) controls numerous other myocyte activities, including gene transcription. Cardiac Ca(2+) signaling essentially relies on a few critical molecular players--ryanodine receptors, voltage-operated Ca(2+) channels, and Ca(2+) pumps/transporters. These moieties are responsible… CONTINUE READING