Calcium signaling in a genetically engineered human pancreatic β-cell line.

@article{Krishnan2015CalciumSI,
  title={Calcium signaling in a genetically engineered human pancreatic β-cell line.},
  author={Kalaiselvan Krishnan and Zuheng Ma and Anneli Bj{\"o}rklund and Md Shahidul Islam},
  journal={Pancreas},
  year={2015},
  volume={44 5},
  pages={773-7}
}
OBJECTIVES The use of primary human β-cells for studying Ca signaling is limited by the scarcity of human pancreatic islets. Rodent insulinoma cell lines are widely used, but it is difficult to extrapolate results obtained from rodent cells to human. Recently, a genetically engineered human β-cell line EndoC-BH1 has been developed. We have examined whether the EndoC-BH1 cells could be used as a model for studying Ca signaling in the β-cells. METHODS We used microscope-based fluorometry to… CONTINUE READING
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