Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers.

@article{So2009CalciumSB,
  title={Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers.},
  author={Christopher H. So and Vaneeta Verma and Mohammad Alijaniaram and Regina Cheng and Asim J. Rashid and Brian F O'dowd and Susan R. George},
  journal={Molecular pharmacology},
  year={2009},
  volume={75 4},
  pages={843-54}
}
In this report, we investigated whether the D5 dopamine receptor, given its structural and sequence homology with the D1 receptor, could interact with the D2 receptor to mediate a calcium signal similar to the G(q/11) protein-linked phospholipase C-mediated calcium signal resulting from the coactivation of D1 and D2 dopamine receptors within D1-D2 receptor heterooligomers. Fluorescent resonance energy transfer experiments demonstrated close colocalization of cell surface D5 and D2 receptors… CONTINUE READING
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