Calcium signaling: A tale for all seasons

  title={Calcium signaling: A tale for all seasons},
  author={Ernesto Carafoli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={1115 - 1122}
  • E. Carafoli
  • Published 5 February 2002
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
An experiment performed in London nearly 120 years ago, which by today's standards would be considered unacceptably sloppy, marked the beginning of the calcium (Ca2+) signaling saga. Sidney Ringer [Ringer, S. (1883) J. Physiol. 4, 29–43] was studying the contraction of isolated rat hearts. In earlier experiments, Ringer had suspended them in a saline medium for which he admitted to having used London tap water, which is hard: The hearts contracted beautifully. When he proceeded to replace the… 

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