Calcium sensitivity of force production and myofibrillar ATPase activity in muscles from Thoroughbreds with recurrent exertional rhabdomyolysis.


OBJECTIVE To determine whether the basis for recurrent exertional rhabdomyolysis (RER) in Thoroughbreds lies in an alteration in the activation and regulation of the myofibrillar contractile apparatus by ionized calcium. ANIMALS 4 Thoroughbred mares with RER and 4 clinically normal (control) Thoroughbreds. PROCEDURES Single chemically-skinned type-I… (More)