Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains.

@article{Davis2002CalciumsensitivePB,
  title={Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains.},
  author={Dawn Belt Davis and Katherine R Doherty and Anthony J Delmonte and E. M. McNally},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 25},
  pages={22883-8}
}
Mutations in dysferlin, a novel membrane protein of unknown function, lead to muscular dystrophy. Myoferlin is highly homologous to dysferlin and like dysferlin is a plasma membrane protein with six C2 domains highly expressed in muscle. C2 domains are found in a variety of membrane-associated proteins where they have been implicated in calcium, phospholipid, and protein-binding. We investigated the pattern of dysferlin and myoferlin expression in a cell culture model of muscle development and… CONTINUE READING

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