Calcium-sensing receptor modulates cell adhesion and migration via integrins.

@article{Tharmalingam2011CalciumsensingRM,
  title={Calcium-sensing receptor modulates cell adhesion and migration via integrins.},
  author={Sujeenthar Tharmalingam and Avais M. Daulat and Jordan E. Antflick and Syed Munaf Ahmed and Edward F. Nemeth and St{\'e}phane Angers and Arthur D. Conigrave and David R. Hampson},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 47},
  pages={40922-33}
}
The calcium-sensing receptor (CaSR) is a family C G protein-coupled receptor that is activated by elevated levels of extracellular divalent cations. The CaSR couples to members of the G(q) family of G proteins, and in the endocrine system this receptor is instrumental in regulating the release of parathyroid hormone from the parathyroid gland and calcitonin from thyroid cells. Here, we demonstrate that in medullary thyroid carcinoma cells, the CaSR promotes cellular adhesion and migration via… CONTINUE READING

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