Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.

@article{Feng2010CalciumsensingRI,
  title={Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.},
  author={Jianying Feng and Clark D Petersen and D. H. Coy. E. J. Coy and Jian-kang Jiang and Craig J. Thomas and Martin R. Pollak and Stephen Wank},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 41},
  pages={17791-6}
}
The calcium-sensing receptor (CaR) is the major sensor and regulator of extracellular Ca(2+), whose activity is allosterically regulated by amino acids and pH. Recently, CaR has been identified in the stomach and intestinal tract, where it has been proposed to function in a non-Ca(2+) homeostatic capacity. Luminal nutrients, such as Ca(2+) and amino acids, have been recognized for decades as potent stimulants for gastrin and acid secretion, although the molecular basis for their recognition… CONTINUE READING
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