Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation.

@article{Yano2004CalciumsensingRA,
  title={Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation.},
  author={Shozo Yano and R. John Macleod and Naibedya Chattopadhyay and Jacob Tfelt-Hansen and Olga Kifor and Robert R Butters and Edward Meigs Brown},
  journal={Bone},
  year={2004},
  volume={35 3},
  pages={664-72}
}
We have previously reported that high extracellular Ca2+ stimulates parathyroid hormone-related protein (PTHrP) release from human prostate and breast cancer cell lines as well as from H-500 rat Leydig cancer cells, an action mediated by the calcium-sensing receptor (CaR). Activating the CaR leads to phosphorylation of mitogen-activated protein kinases (MAPKs) that participate in PTHrP synthesis and secretion. Because the CaR is a G protein-coupled receptor (GPCR), it is likely to transactivate… CONTINUE READING

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