Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.

@article{Pi2002CalciumsensingRA,
  title={Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.},
  author={Min Pi and Robert F Spurney and Qisheng Tu and Todd K. Hinson and Leigh Quarles},
  journal={Endocrinology},
  year={2002},
  volume={143 10},
  pages={3830-8}
}
We investigated the role of Galphaq, filamin, Rho, the RhoGEF Lbc, and the C terminus of calcium-sensing receptor (CasR) in CasR signaling. We found that Ca(2+), Mg(2+), or the calcimimetic R isomer of N-(3-[2-chlorophenyl]propyl)-(R)-alpha-methyl-3-methoxybenzylamine (NPS-R568) stimulated serum response element (SRE) activity human embryonic kidney 293 cells transfected with CasR and an SRE-luciferase reporter construct. Coexpression of either the dominant negative Galphaq(305-359) minigene… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…