Calcium-sensing receptor activation depresses synaptic transmission.

  title={Calcium-sensing receptor activation depresses synaptic transmission.},
  author={Cecilia G Phillips and Mark T. Harnett and Wenyan Chen and Stephen M Smith},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 46},
At excitatory synapses, decreases in cleft [Ca] arising from activity-dependent transmembrane Ca flux reduce the probability of subsequent transmitter release. Intense neural activity, induced by physiological and pathological stimuli, disturb the external microenvironment reducing extracellular [Ca] ([Ca](o)) and thus may impair neurotransmission. Increases in [Ca](o) activate the extracellular calcium sensing receptor (CaSR) which in turn inhibits nonselective cation channels at the majority… CONTINUE READING
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calcium sensing and extracellular calcium signaling

  • EM Brown, G Gamba, +7 authors SC Hebert
  • Physiol Rev
  • 1993
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